The Journal of Organic Chemistry

Diastereoselective and enantioselective total synthesis of the hepatoprotective agent clausenamide

W Hartwig, L Born

Index: Hartwig, Wolfgang; Born, Liborius Journal of Organic Chemistry, 1987 ,  vol. 52,  # 19  p. 4352 - 4358

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Citation Number: 99

Abstract

In Chinese folk-medicine the aqueous extract of the leaves of the plant Clausena lansium (lour) skeels is held to be an efficacious liver protecting agent and is used in cases of acute and chronic viral hepatitis. Scientists at the Institute of Materia Medica of the Chinese Academy of Medical Sciences in Peking1 have studied this plant extract and have isolated as the main component of the extract y-lactam l2 called clausenamide, occuring at about 4 ...

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