Novel ofloxacin derivatives: synthesis, antimycobacterial and toxicological evaluation

M Dinakaran, P Senthilkumar, P Yogeeswari…

Index: Dinakaran, Murugesan; Senthilkumar, Palaniappan; Yogeeswari, Perumal; China, Arnab; Nagaraja, Valakunja; Sriram, Dharmarajan Bioorganic and Medicinal Chemistry Letters, 2008 ,  vol. 18,  # 3  p. 1229 - 1236

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Citation Number: 51

Abstract

Thirty novel 9-fluoro-2, 3-dihydro-8, 10-(mono/di-sub)-3-methyl-8-nitro-7-oxo-7H-[1, 4] oxazino [2, 3, 4-ij] quinoline-6-carboxylic acids were synthesized from 2, 3, 4, 5-tetrafluoro benzoic acid and evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis H37Rv (MTB), multi-drug resistant Mycobacterium tuberculosis (MDR-TB), and Mycobacterium smegmatis (MC2) and also tested for the ability to inhibit ...