The novel (-)-(S)-2 and (+)-(R)-3 enantiomers of 2-nitrooxyethyl 1, 4-dihydro-2, 6-dimethyl-3- nitro-4-(2-trifluoromethylphenyl) pyridine-5-carboxylate were synthesized for evaluation as calcium channel modulators. Determination of their in vitro calcium-channel-modulating