Synthesis of pyrimidino [4, 5??b][1, 5] benzodiazepin??2??ones and pyrimidino [1, 6??a] benzimidazol??1??ones from 4??ethoxycarbonylamino??1H??1, 5??benzodiazpine??3?? …

K Takagi, T Aotsuka, Y Okamoto

Index: Takagi, Kaname; Aotsuka, Tomoji; Morita, Hikari; Okamoto, Yoshihisa Journal of Heterocyclic Chemistry, 1986 ,  vol. 23, p. 1443 - 1449

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Citation Number: 9

Abstract

Abstract Reactions of 4-ethoxycarbonylamino-1H-1, 5-benzodiazepine-3-carbonitrile (2) with aliphatic primary amines gave 1-substituted 4-(2-aminoanilino) pyrimidin-2 (1H)-one-5- carbonitriles 3. Analogous reactions of 2 with aromatic primary amines afforded 2-(2′- anilino-1′-cyanovinyl) benzimidazoles 5 and 6. Upon treatment with triethylamine, 3 underwent intramolecular cyclization to give 3-substituted 5-aminopyrimidino [4, 5-b]-[1, 5] ...