Molecular determinants of the platelet aggregation inhibitory activity of carbamoylpiperidines

Z Feng, R Gollamudi, EO Dillingham…

Index: Feng, Zixia; Gollamudi, Ramachander; Dillingham, Elwood O.; Bond, Stephen E.; Lyman, Beverly A.; et, al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2952 - 2958

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Citation Number: 22

Abstract

A series of a, a'-bis [3-(N~-dialkylcarbamoy1) piperidino]-p-xylenes were synthesized and tested for their inhibitory activity on ADP-induced aggregation of human platelets. A parabolic curve was obtained when log 1/C (activity) was plotted against log P (octanol/water partition coefficient). Using this as a model, a new analogue, a, a'-bis-[3-(N- methyl-N-butylcarbamoyl) piperidino]-p-xylene (3g), was synthesized with a predicted ICw ...