A Versatile Enantioselective Synthesis of Azabicyclic Ring Systems: A Concise Total Synthesis of (+)??Grandisine D and Unnatural Analogues

…, TJ Senter, KN Hahn, CW Lindsley

Index: Fadeyi, Olugbeminiyi O.; Senter, Timothy J.; Hahn, Kristopher N.; Lindsley, Craig W. Chemistry - A European Journal, 2012 , vol. 18, # 19 p. 5826 - 5831

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Citation Number: 16

Abstract

Azabicyclic ring skeletons are common structural subunits present in numerous alkaloid natural products and serve as important scaffolds in biologically active and pharmaceutically significant compounds.[1] Of particular interest in our laboratory (Figure1), are the indolizidine 1, pyrroloACHTUNGTRENNUNG [1, 2-a] azepine 2, and pyrroloACHTUNGTRENNUNG [1, 2-a] azocine 3 azabicyclic systems,[1] which are found ...