Mechanistic analysis of muraymycin analogues: a guide to the design of MraY inhibitors

…, H Oyama, S Ichikawa, A Matsuda

Index: Tanino, Tetsuya; Ichikawa, Satoshi; Matsuda, Akira Organic Letters, 2011 , vol. 13, # 15 p. 4028 - 4031

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Citation Number: 34

Abstract

The systematic structure–activity relationship (SAR) of the muraymycins (MRYs) using an Ugi four-component reaction (U4CR) was investigated. The impact of the lipophilic substituent on antibacterial activity was significant, and the analogues 8 and 9 having a