Chemistry of heterocyclic compounds. 61. Synthesis and conformational studies of macrocycles possessing 1, 8-or 1, 5-naphthyridino subunits connected by carbon- …

GR Newkome, SJ Garbis, VK Majestic…

Index: Newkome, George R.; Garbis, Sam J.; Majestic, Veronica K.; Fronczek, Frank R.; Chiari, Giacomo Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 833 - 839

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Citation Number: 103

Abstract

Polyethereal macrocycles were prepared from both 2, 6-dichloro-1, 5-naphthyridine(2) and 2, 7-dichloro-1, 8-naphthyridine (6). The" cross-the-face" structures of 1: l macrocycles 7, derived from 2, were confirmed by NMR. The 2, 7-(l, &naphthyridmo) macrocyclic structures 9 and 10 were also supported by NMR data which were indicative of diminished N-electron density, when compared to the parent 1, 8-naphthyridine. Template reactions did not ...