e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron letters
An efficient synthesis of platelet-activating factor (PAF) via 1-0-alkyl-2-O-(3-isoxazolyl)-SN-glycero-3-phosphocholine, a new PAF agonist utilization of the 3- …
Abstract Potent PAF agonists (R)-3a, b were synthesized and converted into PAF. Key steps include Mitsunobu reaction of a chiral secondary alcohol with 3-hydroxyisoxazole as the acidic component, and hydrogenolytic ring cleavage of the resulting 3-isoxazolyloxy group into the inverted alcohol.
