The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption

KM Huttunen, A Mannila, K Laine…

Index: Journal of Medicinal Chemistry, , vol. 52, # 14 p. 4142 - 4148

Full Text: HTML

Citation Number: 30

Abstract

... Journal of Medicinal Chemistry. ... To date, the study of prodrugs of guanidines is confined,(26-30) despite the commonness and importance of guanidines and biguanidines in medical applications.(31, 32) Using typical biodegradable prodrugs, such as amides and carbamates ...