e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Eudistomins AQ,. beta.-carbolines from the antiviral Caribbean tunicate Eudistoma olivaceum

KL Rinehart Jr, J Kobayashi, GC Harbour…

Index: Rinehart,K.B.; Kobayashi,J.; Harbour,G.C. Journal of the American Chemical Society, 1987 , vol. 109, p. 3378

Full Text: HTML

Citation Number: 213

Abstract

Abstract: Seventeen eudistomins have been isolated from the Caribbean colonial tunicate Eudistoma olivaceum. Twelve are@-carbolines-four of them (eudistomins D, J, N, and 0) unsubstituted at CI, three (A, B, and M) with pyrrol-2-yl substituents at CI, and five (G, H, I, P, and Q) with I-pyrrolin-2-yl substituents at CI; five (eudistomins C, E, F, K, and L) are 1, 2, 3, 4- tetrahydro-@-carbolines with an oxathiazepine ring fused at Cl and N-2. Syntheses are ...

1-[3-(1,3-dioxa-2-cyclohexyl)propanoyl]-6-methoxy-β-carboline Structure

1-[3-(1,3-dioxa...

~71%

6-methoxy-1-(pyrrol-2-yl)-β-carboline Structure

6-methoxy-1-(py...

1-carbamoyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline Structure

1-carbamoyl-6-m...

~%

6-methoxy-1-(pyrrol-2-yl)-β-carboline Structure

6-methoxy-1-(py...

1-carbomethoxy-6-methoxy-1,2,3,4-tetrahydro-β-carboline hydrochloride Structure

1-carbomethoxy-...

~%

6-methoxy-1-(pyrrol-2-yl)-β-carboline Structure

6-methoxy-1-(py...

1-cyano-6-methoxy-β-carboline Structure

1-cyano-6-metho...

~%

6-methoxy-1-(pyrrol-2-yl)-β-carboline Structure

6-methoxy-1-(py...

1-carbamoyl-6-methoxy-β-carboline Structure

1-carbamoyl-6-m...

~%

6-methoxy-1-(pyrrol-2-yl)-β-carboline Structure

6-methoxy-1-(py...

1-carbamoyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline Structure

1-carbamoyl-6-m...

~%

1-[3-(1,3-dioxa-2-cyclohexyl)propanoyl]-6-methoxy-β-carboline Structure

1-[3-(1,3-dioxa...

1-carbomethoxy-6-methoxy-1,2,3,4-tetrahydro-β-carboline hydrochloride Structure

1-carbomethoxy-...

~%

1-[3-(1,3-dioxa-2-cyclohexyl)propanoyl]-6-methoxy-β-carboline Structure

1-[3-(1,3-dioxa...

1-carbamoyl-6-methoxy-β-carboline Structure

1-carbamoyl-6-m...

~%

1-[3-(1,3-dioxa-2-cyclohexyl)propanoyl]-6-methoxy-β-carboline Structure

1-[3-(1,3-dioxa...

2,3,4,9-Tetrahydro-1H-b-carboline-1-carboxylic acid Structure

2,3,4,9-Tetrahy...

~%

6-bromo-1-cyano-β-carboline Structure

6-bromo-1-cyano...

1-carbamoyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline Structure

1-carbamoyl-6-m...

~72%

1-carbamoyl-6-methoxy-β-carboline Structure

1-carbamoyl-6-m...

1-carbomethoxy-6-methoxy-1,2,3,4-tetrahydro-β-carboline hydrochloride Structure

1-carbomethoxy-...

~%

1-carbamoyl-6-methoxy-β-carboline Structure

1-carbamoyl-6-m...

1-carbomethoxy-6-methoxy-1,2,3,4-tetrahydro-β-carboline hydrochloride Structure

1-carbomethoxy-...

~79%

1-carbamoyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline Structure

1-carbamoyl-6-m...

1-(1-pyrrolin-5-yl)-β-carboline Structure

1-(1-pyrrolin-5...

~76%

1-(pyrrolidin-2-yl)-β-carboline Structure

1-(pyrrolidin-2...

2,3,4,9-Tetrahydro-1H-b-carboline-1-carboxylic acid Structure

2,3,4,9-Tetrahy...

~%

1-(pyrrolidin-2-yl)-β-carboline Structure

1-(pyrrolidin-2...

1-[1-amino-3-(1,3-dioxa-2-cyclohexyl)propyl]-β-carboline Structure

1-[1-amino-3-(1...

~%

1-(pyrrolidin-2-yl)-β-carboline Structure

1-(pyrrolidin-2...

1-carbamoyl-6-methoxy-β-carboline Structure

1-carbamoyl-6-m...

~68%

1-cyano-6-methoxy-β-carboline Structure

1-cyano-6-metho...

1-carbamoyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline Structure

1-carbamoyl-6-m...

~%

1-cyano-6-methoxy-β-carboline Structure

1-cyano-6-metho...

1-carbomethoxy-6-methoxy-1,2,3,4-tetrahydro-β-carboline hydrochloride Structure

1-carbomethoxy-...

~%

1-cyano-6-methoxy-β-carboline Structure

1-cyano-6-metho...

6-bromo-1-(1-pyrrolin-5-yl)-β-carboline Structure

6-bromo-1-(1-py...

~64%

6-bromo-1-(1-pyrrolidin-2-yl)-β-carboline Structure

6-bromo-1-(1-py...

2,3,4,9-Tetrahydro-1H-b-carboline-1-carboxylic acid Structure

2,3,4,9-Tetrahy...

~%

6-bromo-1-(1-pyrrolidin-2-yl)-β-carboline Structure

6-bromo-1-(1-py...

6-bromo-1-cyano-β-carboline Structure

6-bromo-1-cyano...

~%

6-bromo-1-(1-pyrrolidin-2-yl)-β-carboline Structure

6-bromo-1-(1-py...

6-bromo-1-[1-amino-3-(1,3-dioxa-2-cyclohexyl)propyl]-β-carboline Structure

6-bromo-1-[1-am...

~%

6-bromo-1-(1-pyrrolidin-2-yl)-β-carboline Structure

6-bromo-1-(1-py...

1-[1-amino-3-(1,3-dioxa-2-cyclohexyl)propyl]-β-carboline Structure

1-[1-amino-3-(1...

~77%

1-(1-pyrrolin-5-yl)-β-carboline Structure

1-(1-pyrrolin-5...

2,3,4,9-Tetrahydro-1H-b-carboline-1-carboxylic acid Structure

2,3,4,9-Tetrahy...

~%

1-(1-pyrrolin-5-yl)-β-carboline Structure

1-(1-pyrrolin-5...

6-bromo-1-[1-amino-3-(1,3-dioxa-2-cyclohexyl)propyl]-β-carboline Structure

6-bromo-1-[1-am...

~51%

6-bromo-1-(1-pyrrolin-5-yl)-β-carboline Structure

6-bromo-1-(1-py...

2,3,4,9-Tetrahydro-1H-b-carboline-1-carboxylic acid Structure

2,3,4,9-Tetrahy...

~%

6-bromo-1-(1-pyrrolin-5-yl)-β-carboline Structure

6-bromo-1-(1-py...

6-bromo-1-cyano-β-carboline Structure

6-bromo-1-cyano...

~%

6-bromo-1-(1-pyrrolin-5-yl)-β-carboline Structure

6-bromo-1-(1-py...

2,3,4,9-Tetrahydro-1H-b-carboline-1-carboxylic acid Structure

2,3,4,9-Tetrahy...

~%

6-bromo-1-[1-amino-3-(1,3-dioxa-2-cyclohexyl)propyl]-β-carboline Structure

6-bromo-1-[1-am...

2,3,4,9-Tetrahydro-1H-b-carboline-1-carboxylic acid Structure

2,3,4,9-Tetrahy...

~%

1-[1-amino-3-(1,3-dioxa-2-cyclohexyl)propyl]-β-carboline Structure

1-[1-amino-3-(1...

The chemistry of vicinal tricarbonyl compounds. Short synthe...

[Wasserman, Harry H.; Kelly, Terence A. Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7117 - 7120]

The chemistry of vicinal tricarbonyl compounds. Short synthe...

[Wasserman, Harry H.; Kelly, Terence A. Tetrahedron Letters, 1989 , vol. 30, # 50 p. 7117 - 7120]