Synthesis of activated alkenes bearing the difluoromethylenephosphonate group: a range of building blocks for the synthesis of secondary difluorophosphonates

…, HJ Easterfield, TP Lequeux, JM Percy

Index: Blades, Kevin; Butt, Afshan H.; Stuart Cockerill; Easterfield, Howard J.; Lequeux, Thierry P.; Percy, Jonathan M. Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 24 p. 3609 - 3614

Full Text: HTML

Citation Number: 20

Abstract

Active methylene compounds reacted readily with stable hydrate 2-diethoxyphosphoryl-2, 2- difluoroethane-1, 1-diol to afford a range of activated alkenes bearing the difluoromethylenephosphonate group, a useful motif in the synthesis of phosphate ester mimics of biological interest. Wadsworth–Horner–Emmons reactions were employed using modified Rathke conditions for the syntheses of alkenoates, an alkenoic acid and a vinyl ...