Tetrahedron Letters

The 2-(methylthiomethoxy) ethoxycarbonyl [mtmec] protecting group

SS Jones, CB Reese, S Sibanda

Index: Jones, Simon S.; Reese, Colin B.; Sibanda, Samson Tetrahedron Letters, 1981 , vol. 22, # 20 p. 1933 - 1936

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Citation Number: 7

Abstract

Summary: Alcohols (ROH) may be converted into their MTMEC deri_vatives (6) by acylation with 2-(methylthiomethoxyJethoxycarbony1 chloride (2); the MTMEC" protected protecting group" may be removed by treatment first with Hg (I1) perchlorate in the presence of 2, 4, 6- collidine or pyridine in acetone-water solution, followed by hydrolysis under very mild basic conditions.