Radical Cyclization of N??Acylcyanamides: Total Synthesis of Luotonin A

…, D Lopes, C Courillon, M Malacria

Index: Servais, Aurore; Azzouz, Meriam; Lopes, David; Courillon, Christine; Malacria, Max Angewandte Chemie - International Edition, 2007 ,  vol. 46,  # 4  p. 576 - 579

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Citation Number: 75

Abstract

Heterocyclic compounds are of particular interest in medicinal science. This has accelerated the quest for new methods in heterocyclic chemistry. A particular class of alkaloids that incorporate the pyrroloquinazoline chromophore have been isolated from natural sources [1] and display a wide range of biological activities.[2] Among them, luotonin A is a human DNA topoisomerase I poison, which has been isolated from Peganum nigellastrum, a Chinese ...