Pharmacol. Ther. 1989, 41,339). A glutathione-based detoxification pathway leads to the formation of the mercapturic acid conjugates [NaphMA 1,(R)-N-acetyl-S-[(lR*, 2R*)-1, 2- dihydo-l-hydroxy-2-naphthyllcysteine and (R)-N-acetyl-S-[(1R*, 2R*)-1, 2-dihydro-2-hydroxy- l-naphthyl] c~ teine] which are excreted in urine. Herein we report the development of an immunoassay for the specific detection of these urinary metabolites. This study confirms ...
