Abstract (−)-α-Conidendrin 1 was synthesized according to a general reactionscheme that could be applied to other retrolignans as well. Thus, treatment of the optically active β-benzyl- γ-butyrolactone (R)-(+)-4 with NBS, followed with benzyl alcohol, selectively introduced a benzyloxy group in the benzylic position and afforded the mixture of epimers 7. α-Alkylation of the lithium enolate of the corresponding silyl ethers 10, with O-benzylvanillyl bromide ...
![(R)-4-[(4-hydroxy-3-methoxyphenyl)methyl]dihydro-2(3H)-furanone Structure](https://image.chemsrc.com/caspic/194/111266-00-3.png)
