Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores

…, KC Han, CM Torres, DK Bhattacharyya…

Index: Lee, Jeewoo; Kang, Ji-Hye; Lee, Sang-Yoon; Han, Kee-Chung; Torres, Christina M.; Bhattacharyya, Dipak K.; Blumberg, Peter M.; Marquez, Victor E. Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4129 - 4139

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Citation Number: 11

Abstract

A series of substituted tetrahydrofurans with an embedded glycerol backbone carrying additional tetrahydrofuranylideneacetate or tetrahydrofuranylacetate motifs were grouped into four distinct templates (I-IV) according to stereochemistry. The compounds were designed to mimic three essential pharmacophores (C3-CO, C20-OH and C13-CO) of the phorbol esters according to a new, revised model. The tetrahydrofuran ring was ...