Imidazole-derived 2-[N-carbamoylmethyl-alkylamino] acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

…, X Marechal, J Dumont, M Hamdane, V Pottiez…

Index: Charton, Julie; Gauriot, Marion; Guo, Qing; Hennuyer, Nathalie; Marechal, Xavier; Dumont, Julie; Hamdane, Malika; Pottiez, Virginie; Landry, Valerie; Sperandio, Olivier; Flipo, Marion; Buee, Luc; Staels, Bart; Leroux, Florence; Tang, Wei-Jen; Deprez, Benoit; Deprez-Poulain, Rebecca European Journal of Medicinal Chemistry, 2014 , vol. 79, p. 184 - 193

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Citation Number: 10

Abstract

Abstract Insulin degrading enzyme (IDE) is a highly conserved zinc metalloprotease that is involved in the clearance of various physiologically peptides like amyloid-beta and insulin. This enzyme has been involved in the physiopathology of diabetes and Alzheimer's ...