Friedel-Crafts reaction with naphthalene is thus significantly solvent dependent. This is not at all unusual in Friedel-Crafts reactions, and variable steric effects are believed to be largely the cause. 13 In this case use of the two different solvents facilitates the isolation of each of the two desired isomeric diketones. The lH and 13C NMR spectra of 11-13 are clearly indicative of their structures (see Experimental Section).
[Wilson, Martin P.; Bowman, Ralph E.; Smith, H. John; Nicholls, Paul J.; Hewlins, Michael J. E. Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 2 p. 160 - 171]
[Wilson, Martin P.; Bowman, Ralph E.; Smith, H. John; Nicholls, Paul J.; Hewlins, Michael J. E. Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 2 p. 160 - 171]
