Steroids

The synthesis of spermine analogs of the shark aminosterol squalamine

Y Shu, SR Jones, WA Kinney, BS Selinsky

Index: Shu, Youheng; Jones, Stephen R; Kinney, William A; Selinsky, Barry S Steroids, 2002 , vol. 67, # 3-4 p. 291 - 304

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Citation Number: 52

Abstract

Aminosterols isolated from the dogfish shark Squalus acanthias are promising therapeutic agents in the treatment of infection and cancer. One of these, MSI-1436, has been shown to possess antimicrobial activity slightly better than squalamine. In this study, a series of analogs of MSI-1436 have been synthesized from stigmasterol. The 7α-hydroxy substituent of MSI-1436 was either omitted or the stereochemistry modified to the 7β position. Also, ...