Tetrahydroisoquinoline derivatives as melatonin MT 2 receptor antagonists

GN Karageorge, S Bertenshaw, L Iben, C Xu…

Index: Karageorge, George N.; Bertenshaw, Stephen; Iben, Lawrence; Xu, Cen; Sarbin, Nathan; Gentile, Anthony; Dubowchik, Gene M. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5881 - 5884

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Citation Number: 12

Abstract

... 1 Cloning of several melatonin receptor genes has revealed at least three melatonin receptor proteins. ... Scheme 1. Reagents and conditions: (a) formic acid 95 °C, ∼50% yield; (b) R 6 (C O)Cl, Et 3 N, CH 2 Cl 2 or R 6 (C O)Cl, poly(4-vinylpyridine), dichloroethane, Wa21J (Supelco) polyamine scavenging resin, rt (42–88% yield). ... 181–190. [5]; RJ Mattson, JD Catt, D. Keavy, CP Sloan, J. Epperson, Q. Gao, DB Hodges, L. Iben, CD Mahle, E. Ryan, FD Yocca; ...