Solvent??free chemoselective synthesis of some novel substituted 2??arylbenzimidazoles using amino acid??based prolinium nitrate ionic liquid as catalyst

S Rostamizadeh, R Aryan, HR Ghaieni…

Index: Rostamizadeh, Shahnaz; Aryan, Reza; Ghaieni, Hamid Reza; Amani, Ali Mohammad Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 1 p. 74 - 78

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Citation Number: 21

Abstract

The benzimidazole ring system is an important pharmacophore in medicinal chemistry and modern drug discovery. Benzimidazole derivatives exhibit activities against several viruses such as influenza [1a], human cytomegalovirus [1b], and HIV [1c]. Benzimidazole and its derivatives have also been known to act as topoisomerase inhibitors [2], selective neuropeptide YY 1 receptor antagonists [3], potential antitumor [4] and antimicrobial ...