Tetrahedron

Synthesis of functionalized diaryl sulfides based on regioselective one-pot cyclizations of 1, 3-bis (trimethylsilyloxy)-1, 3-butadienes

…, N Rasool, M Adeel, H Reinke, C Fischer, P Langer

Index: Rashid, Muhammad A.; Rasool, Nasir; Adeel, Muhammad; Reinke, Helmut; Fischer, Christine; Langer, Peter Tetrahedron, 2008 , vol. 64, # 17 p. 3782 - 3793

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Citation Number: 17

Abstract

A variety of pharmacologically relevant diaryl sulfides (diaryl thioethers) have been isolated as natural products. 1, 1a, 1b, 1c, 1d, 1e, 1f, 1g and 1h Non-natural diaryl sulfides are also of considerable pharmacological relevance. For example, fluorinated diaryl sulfides have been reported to act as serotonin transporter ligands. 2 Most of the known synthetic approaches to diaryl sulfides are based on the formation of a carbon–sulfur bond. Classic syntheses (such as the ...