Chemical carcinogenesis. 93. Synthesis of potential phenolic metabolites of benzo [b] fluoranthene

S Amin, K Huie, N Hussain, G Balanikas…

Index: Amin, Shantu; Huie, Keith; Hussain, Nalband; Balanikas, George; Carmella, Steven G.; Hecht, Stephen S. Journal of Organic Chemistry, 1986 ,  vol. 51,  # 8  p. 1206 - 1211

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Citation Number: 19

Abstract

The syntheses of the 12 isomeric hydroxybenzo [blfluoranthenes (hydroxy-BbF, 1-12) are described. 1-Hydroxy-BbF was prepared by treatment of l-ox0-1, 2, 3, 3a-tetrahydro-BbF (13) with Pd/C. 2-Hydroxy-BbF was synthesized by reduction of 13 with NaBH,, followed by dehydration, epoxidation, and treatment with PdIC. 3-Hydroxy-BbF was obtained by reduction of 13 with Zn (Hg) followed by oxidation with Triton-B, dehydration, epoxidation, ...