Tetramic acid derivatives are the key structural core found in a variety of natural products including many antibiotics such as melophilin B, reutericyclin, tirandamycin, BU2313A, blasticidin A and vancoresmycin. 1, 2, 3, 4 and 5 The wide spectrum of biological activities in this class of molecule include potent antiviral, antibiotic and antifungal properties as well as cytotoxicities and antitumour action. 6, 7 and 8 These compounds have also been designed as glycine site N-methyl-d- ...
