Isolation and structure elucidation of cruentarens A and b—novel members of the benzolactone class of ATPase inhibitors from the Myxobacterium Byssovorax …

L Jundt, H Steinmetz, P Luger, M Weber…

Index: Jundt, Larissa; Steinmetz, Heinrich; Luger, Peter; Weber, Manuela; Kunze, Brigitte; Reichenbach, Hans; Hoefle, Gerhard European Journal of Organic Chemistry, 2006 , # 22 p. 5036 - 5044

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Citation Number: 23

Abstract

Abstract Two novel secondary metabolites, namely cruentaren A (1) and B (2), have been isolated from the myxobacterium Byssovorax cruenta. Their structures have been elucidated by detailed NMR spectroscopic analysis. Both compounds are isomers of a C 22 polyketide with a 2-hydroxy-4-methoxybenzoic acid terminus, which forms a 12-membered lactone in 1 and a six-membered lactone in 2. An amino group at C-22 is acylated by a 3-hydroxy-2- ...