Synthesis

Simple preparation of N-benzyl-β-aminohydroxamic acids by 1, 3-dipolar cycloaddition of nitrones

C Chevrier, A Defoin

Index: Chevrier, Carine; Defoin, Albert Synthesis, 2003 , # 8 p. 1221 - 1224

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Citation Number: 5

Abstract

Abstract β-Aminohydroxamic acids 6a-d are prepared in 4 steps and 30-45% overall yield from nitrones 1a-d by 1, 3-dipolar cycloaddition with phenyl vinyl ether, N-benzylation, thermal rearrangement, and nucleophilic substitution of the formed phenyl ester with hydroxylamine.