Antimicrobial, analgesic, DPPH scavenging activities and molecular docking study of some 1, 3, 5-triaryl-2-pyrazolines

S Samshuddin, B Narayana, BK Sarojini…

Index: Samshuddin, Seranthimata; Narayana, Badiadka; Sarojini, Balladka Kunhanna; Raj, Chenna Govindaraju Darshan; Khan, Mahmud Tareq Hassan; Yathirajan, Hemmige S.; Raghavendra, Ramappa Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 2012 - 2022,11

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Citation Number: 26

Abstract

Abstract A series of 1, 3, 5-triaryl-2-pyrazolines 2a–g were synthesized by the reaction of 4, 4′-disubstituted chalcone with phenyl hydrazine. All these compounds were characterized by NMR, IR and mass spectral and single crystal XRD data. All the synthesized products were screened for their in vitro antimicrobial, analgesic and antioxidant properties. The docking studies were carried out for these compounds against the active site of methionyl- ...