Synthesis and pharmacological evaluation of 2, 5-cycloamino-5H-[1] benzopyrano [4, 3-d] pyrimidines endowed with in vitro antiplatelet activity

…, C Brullo, A Ranise, S Schenone, F Bondavalli…

Index: Bruno; Brullo; Ranise; Schenone; Bondavalli; Barocelli; Ballabeni; Chiavarini; Tognolini; Impicciatore Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1397 - 1400

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Citation Number: 47

Abstract

A series of new 2, 5-cycloamino-5H-[1] benzopyrano [4, 3-d] pyrimidines 3a–i have been synthesized and tested in vivo for the anti-inflammatory/analgesic/antipyretic effects and in vitro to evaluate the antiplatelet activity on guinea-pig platelet-rich plasma aggregated by collagen, adenosine-5′-diphosphate (ADP) and arachidonic acid (AA). Title compounds were ineffective in vivo; however, the pyrrolidino derivatives 3a and 3c exhibited an ...