Australian Journal of Chemistry

The chemistry of 2, 1-benzisothiazoles. IX. The reaction of 3-chloro-substituted 2, 1-benzisothiazoles with nucleophiles and the preparation of (2, 1-Benzisothiazol-3-yl …

M Davis, E Homfeld, J McVicars, S Pogany

Index: Davis,M. et al. Australian Journal of Chemistry, 1975 , vol. 28, p. 2051 - 2055

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Citation Number: 3

Abstract

Abstract 3-Chloro-2, 1-benzisothiazole (2; R= H, R?= Cl) and 3, 5-dichloro-2, 1- benzisothiazole (2; R, R?= Cl) react readily with nucleophiles, and yield 3-substituted products. Acid hydrolysis of one such product, ethyl (2, 1-benzisothiazol-3-yl) cyanoacetate (2; R= H, R?= CH (CN) CO 2 Et), affords (2, 1-benzisothiazol-3-yl) acetic acid (2; R= H, R?= CH 2 CO 2 H), an auxin analogue.