2b quisite 6-aminoquinazoline with diethyl p-formylbenzoyl-L-glutamate were unsuccessful, yielding extremely complex reaction mixtures. While this approach was successful in the case of 6-aminoquinazolines possessing either hydrogen or methyl at position 5, 5J0 the presence of the electron-withdrawing chlorine atom at position 5 apparently renders the 6- amino function insufficiently nucleophilic to effect clean reductive condensation in the ...
