Tetrahedron: Asymmetry

Two new efficient preparations of enantiopure 2, 2′-dihydroxy-6, 6′-dimethoxy-1, 1′-biphenyl

G Delogu, D Fabbri

Index: Delogu, Giovanna; Fabbri, Davide Tetrahedron Asymmetry, 1997 , vol. 8, # 5 p. 759 - 763

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Citation Number: 28

Abstract

Two new useful methods for the preparation of diol 1 starting from available compounds are described. Separation of the two enantiomers entails resolutin of racemic diol 1 via the corresponding diastereomeric N-methylated phosphorothioamidates. Their separation by recrystallization followed by reduction afforded diol (aS)-1 and (aR)-1 in 100% and 72% ee, respectively.