Journal of the American Chemical Society

Quantitative dealkylation of alkyl esters via treatment with trimethylsilyl iodide. A new method for ester hydrolysis

MF Jung, MA Lyster

Index: Jung,M.E.; Lyster,M.A. Journal of the American Chemical Society, 1977 , vol. 99, # 3 p. 968 - 969

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Citation Number: 216

Abstract

Sir: The hydrolysis of alkyl carboxylic esters is usually carried out under acidic or basic conditions. Recently, several procedures have been developed which allow for hydrolysis under neutral conditions. I However, these procedures usually require the use of strong nucleophiles and high temperatures to effect dealkylation. We wish to report a very mild and extremely efficient alternative to the above methods, which proceeds in essentially ...