Abstract Hippuric acid was converted to α-Y-substituted tetramic acids (Y=-CN,-CO 2 R and- COCH 3) according to the following general scheme of reactions: a) preparation of the hippuric acid chloride or of its p-nitrophenyl ester; b) C-acylation of an active methylene compound Y-CH 2-CO 2 R using the acid chloride or the active ester; and c) intramolecular condensation of the C-acylation compound to an α-Y-substituted tetramic acid. The ...
