Tetrahedron letters

Regiocontrolled synthesis of highly-functionalized fused imidazoles: a novel synthesis of second generation LFA-1 inhibitors

RP Frutos, M Johnson

Index: Frutos, Rogelio P.; Johnson, Michael Tetrahedron Letters, 2003 ,  vol. 44,  # 34  p. 6509 - 6511

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Citation Number: 15

Abstract

A new and reliable route to a new class of LFA-1 inhibitors such as (2) has been developed. A key aspect of this route is the transformation of amino amide 5 into iodide 3 in four steps. Iodide 3 is a key advanced intermediate used in the synthesis of all second-generation 1H- imidazo [1, 2-α] imidazol-2-one LFA-1 inhibitors.