A new synthetic route of 4-(4-methyl-4-hydroxyamyl)-Δ3-cyclohexenecarboxaldehyde (Lyral) from myrcene (1) was investigated. It involves subjecting 1 first to the diene synthesis with acrolein (2) followed by hydration of the morpholine enamine of the adduct in 50% sulfuric acid at 0-5° and the subsequent hydrolysis in diluted sulfuric acid at 15-20°. The present method is superior in simplicity as well as productivity for the preparation of Lyral to any ...
