A Versatile Synthesis of Meyers' Bicyclic Lactams from Furans: Singlet??Oxygen??Initiated Reaction Cascade

…, I Alexopoulou, G Vassilikogiannakis

Index: Kalaitzakis, Dimitris; Montagnon, Tamsyn; Alexopoulou, Ioanna; Vassilikogiannakis, Georgios Angewandte Chemie - International Edition, 2012 , vol. 51, # 35 p. 8868 - 8871

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Citation Number: 24

Abstract

Ever since they were pioneered by Meyers the homochiral bicyclic lactams [1, 2] bearing his name (B, Scheme 1) have been exceedingly popular and versatile scaffolds for the enantioselective construction of new stereogenic centers, including the most challenging type, quaternary carbon centers. These bicyclic lactams have been utilized in a myriad of different ways in the synthesis of a wide variety of natural products [2, 3] and nonnatural ...