Abstract The C-acylation reactions of the methyl cyanoacetate with N-protected glycines by simultaneous activation of the amino acid carbonyl group and the methyl cyanoacetate methylene group using carbonyl diimidazole (CDI) have been here performed. The corresponding aminoacetylcyanoacetates were isolated (devoided of any impurities) as enols 4 in high yields, with a simple experimental, one pot, procedure.
