Synthesis and Structure− Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H4 Receptor Agonists §

…, S Dove, R Seifert, A Buschauer

Index: Igel, Patrick; Schneider, Erich; Schnell, David; Elz, Sigurd; Seifert, Roland; Buschauer, Armin Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2623 - 2627

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Citation Number: 64

Abstract

Recently, we identified high-affinity human histamine H3 (hH3R) and H4 receptor (hH4R) ligands among a series of NG-acylated imidazolylpropylguanidines, which were originally designed as histamine H2 receptor (H2R) agonists. Aiming at selectivity for hH4R, the acylguanidine group was replaced with related moieties. Within a series of cyanoguanidines, 2-cyano-1-[4-(1 H-imidazol-4-yl) butyl]-3-[(2-phenylthio) ethyl] ...