Tetrahedron

Novel synthetic routes to thienocarbazoles via palladium or copper catalyzed amination or amidation of arylhalides and intramolecular cyclization

ICFR Ferreira, MJRP Queiroz, G Kirsch

Index: Ferreira, Isabel C.F.R; Queiroz, Maria-Joao R.P; Kirsch, Gilbert Tetrahedron, 2002 , vol. 58, # 39 p. 7943 - 7949

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Citation Number: 44

Abstract

Palladium or copper catalyzed aminations or amidations were performed to obtain diarylamines and diarylacetamides precursors of thienocarbazoles. The fact that an ortho- bromodiarylamine did not cyclize to the corresponding thienocarbazole under conditions known for carbazoles from ortho-halodiphenylamines, conducted us to a highly efficient method of palladium-catalyzed intramolecular cyclization with N-deprotection of ortho- ...