Bioorganic & medicinal chemistry letters

Non-steroidal pregnancy-terminating agents: design, synthesis and structure–activity relationships of 2-aryl-1, 2, 4-triazolo [1, 5-a] pyridine

T Liu, Y Hu

Index: Liu, Tao; Hu, Yongzhou Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 17 p. 2411 - 2413

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Citation Number: 10

Abstract

The syntheses and the pregnancy-terminating activity relationships of compounds 5a–n are reported. Compounds 5b and 5l are found to be more potent than DL-111—a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and 5l have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration.