Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor

…, X Wang, GT Wang, J Cohen, WZ Gu, H Zhang…

Index: Lin, Nan-Horng; Wang, Le; Wang, Xilu; Wang, Gary T.; Cohen, Jerry; Gu, Wen-Zhen; Zhang, Haiying; Rosenberg, Saul H.; Sham, Hing L. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 20 p. 5057 - 5062

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Citation Number: 23

Abstract

Farnesyltransferase inhibitors (FTIs) have emerged as a novel class of anti-cancer agents. Analogs of the potent FTI, 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole, were synthesized and tested in vitro for their inhibitory activities. The most promising compound identified from this series is analog 29 that possesses potent enzymatic and cellular activities.