Comparative study on the antioxidant and biological activities of carvacrol, thymol, and eugenol derivatives

…, V Smrečki, N Žarković, K Brčić-Kostic…

Index: Mastelic, Josip; Jerkovic, Igor; Blazevic, Ivica; Poljak-Blazi, Marija; Borovic, Suzana; Ivancic-Bace, Ivana; Smrecki, Vilko; Zarkovic, Neven; Brcic-Kostic, Krunoslav; Vikic-Topic, Drazen; Mueller, Norbert Journal of Agricultural and Food Chemistry, 2008 , vol. 56, # 11 p. 3989 - 3996

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Citation Number: 119

Abstract

Four derivatives of thymol, carvacrol, and eugenol were synthesized: 4-(hydroxymethyl)-5- isopropyl-2-methylphenol, 4, 4′-methylenebis (5-isopropyl-2-methyl) phenol, 4-allyl-6- (hydroxymethyl)-2-methoxyphenol, and 4-(hydroxymethyl)-2-isopropyl-5-methylphenol. The obtained derivatives showed remarkably better antioxidative properties according to 1, 1- diphenyl-2-picrylhydrazyl assay (50% inhibitory concentrations= 4–156 µg/mL) and ...