Treatment of P-epoxy-sulphone, -sulphoxide, and -ester with Grignard reagents and copper(1) iodide in diethyl ether-tetrahydrofuran at low temperature leads to rapid ring opening without loss of chirality. ... Organometallic compounds such as organocuprates are useful reagents for nucleophilic ring opening of epoxides,l--3 and the treatment of epoxides containing a carbonyl group at the a-position with organocuprates results in nucleophilic ring
