Studies on Organic Sulfur Compounds. XI. Synthesis of 2-Alkylthio-thiazolo [3, 2-a]-s-triazine-4-ones

M NAGANO, T MATSUI, J TOBITSUKA…

Index: Nagano,M. et al. Chemical and Pharmaceutical Bulletin, 1973 , vol. 21, p. 74 - 86

Full Text: HTML

Citation Number: 8

Abstract

1-Alkoxycarbonyl-3-(2-thiazolyl) thioureas (A) were reacted with alkyl halides in presence of potassium carbonate to afford 1 (H)-alkoxycarbony1-2-alkyl-3-(2-thiazolyl)-isothioureas (D), 1-alkoxycarbony1-2-alkyl-3-(3-alkylthiazolin-2-ylidene) isothioureas (E) 2-alkylthio-thiazolo [3, 2-a]-s-triazine-4-ones (C). However, the rate of this reaction the yields of the products were dependent on the kinds of alkyl halide and thiazolyl thioureas (A). The cyclization ...