Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity

…, J Bignon, J Wdzieczak-Bakala, D Desravines…

Index: Rasolofonjatovo, Evelia; Provot, Olivier; Hamze, Abdallah; Rodrigo, Jordi; Bignon, Jerome; Wdzieczak-Bakala, Joanna; Desravines, Deborah; Dubois, Joelle; Brion, Jean-Daniel; Alami, Mouad European Journal of Medicinal Chemistry, 2012 , vol. 52, p. 22 - 32

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Citation Number: 29

Abstract

A novel series of dihydronaphtalene, tetrahydronaphtalene and naphtalene derivatives as restricted analogues of isoCA-4 were designed, synthesized and evaluated for their anticancer properties. High cell growth inhibition against four tumour cell lines was observed at a nanomolar level with dihydronaphtalenes 1d, e and 1h, tetrahydronaphtalene 2c and naphtalene 3c. Structure–activity relationships are also considered. These compounds ...