t-Amyloxycarbonyl as a New Protecting Group in Peptide Synthesis. I. The Synthesis and Properties of Nt-Amyloxycarbonylamino Acids and Related Compounds

S Sakakibara, M Shin, M Fujino, Y Shimonishi…

Index: Sakakibara,S. et al. Bulletin of the Chemical Society of Japan, 1965 , vol. 38, p. 1522 - 1525

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Citation Number: 30

Abstract

It has been shown that the t-amyloxycarbonyl group (AOC group) can be introduced quite readily into amino acid esters by using t-amyl chloroformate as a reagent, and that the AOC group can be cleaved as smoothly as the t-butoxycarbonyl group (BOC group) under acidic conditions. Since this reagent is much easier to prepare than any other reagents used for the introduction of the BOC group, the new procedure is considered to be of great use in the ...