A novel and efficient methodology for the CC bond forming radical cyclization of hydrophobic substrates in water

…, H Nambu, NG Ramesh, G Anilkumar, M Matsugi

Index: Kita, Yasuyuki; Nambu, Hisanori; Ramesh, Namakkal G.; Anilkumar, Gopinathan; Matsugi, Masato Organic Letters, 2001 , vol. 3, # 8 p. 1157 - 1160

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Citation Number: 93

Abstract

The combination of water-soluble radical initiator 2, 2'-azobis [2-(2-imidazolin-2-yl) propane](VA-061), water-soluble chain carrier 1-ethylpiperidine hypophosphite (EPHP), and surfactant cetyltrimethylammonium bromide (CTAB) was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates.