Hypoxia-selective antitumor agents. 16. Nitroarylmethyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine

M Tercel, AE Lee, A Hogg, RF Anderson…

Index: Bernard, Marek K.; Makosza, Mieczyslaw; Szafran, Barbara; Wrzeciono, Urszula Liebigs Annalen der Chemie, 1989 , p. 545 - 550

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Citation Number: 46

Abstract

... 9, −500 ± 8, 550 ± 170, 1.6 ± 0.1, 17 ± 2, 215 ± 30, 245 ± 40, 18 ± 10, 16 ± 6. ... to a further compound (8) made use of the vicarious nucleophilic substitution (VNS) strategy reported by Makosza and Bialecki 20 ... a Conditions: (a) Me 2 SO 4 , K 2 CO 3 ; (b) NaBH 4 ; (c) NaOH and then ...