Synthesis of 4-oxo-4, 7-dihydrofuro [2, 3-b] pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition

…, TA Hopkins, ML Knechtel, NL Oien, RS Sackett…

Index: Schnute, Mark E.; Brideau, Roger J.; Collier, Sarah A.; Cudahy, Michele M.; Hopkins, Todd A.; Knechtel, Mary L.; Oien, Nancee L.; Sackett, Robert S.; Scott, Allen; Stephan, Mari L.; Wathen, Michael W.; Wieber, Janet L. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 3856 - 3859

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Citation Number: 18

Abstract

A versatile synthesis of 4-oxo-4, 7-dihydrofuro [2, 3-b] pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.